factor 2 x -12x+35
/in /by adminCriminalist DB4
/in /by admin2-4 paragraphs
ABIS will need to distinguish how the First and Fourth Amendments relate to computer investigations, search warrants, and seizures of computers and other technology in the discussion. It will also discuss several key amendment aspects, which must be known by investigators to execute a successful training discussion.
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“PROFESSOR.JANNET”
/in /by adminA single nucleotide polymorphism (rs10065172 SNP) was reported for the human IRGM gene: a “C” to “T” variation at position 313 of IRGM coding sequence (Transcript ID: IRGM-001 ENST00000522154). This exonic synonymous SNP (defined as “313C>T”) has been associated with increased susceptibilites to an inflammatory disease known as the “Crohn’s disease”.
Additional studies suggested that the microRNA-196 may down-regulate IRGM expression from the protective allele (or the “C” allele), but not from the risk-associated allele (or the “T” allele). Loss of the regulation of IRGM expression has been shown to disrupt cellular autophagy.
The hypothesis is that the 313C>T SNP causes a loss of regulation of IRGM expression by microRNA-196.
MATERIALS AVAILABLE: Crohn’s patient cells (genotype: IRGM 313C/313T), healthy cells (genotype: IRGM 313C/313C). All reagents for DNA, RNA, protein, and cell work are available.
QUESTION:
Please develop an overall strategy, using concepts learned from “genome editing” lectures, to achieve the goal of genetic engineering of IRGM allele in provided cell lines. A flow chart of experimental procedures, accompanied by detailed description of each step, is necessary. Your approach should be sufficient for you to test the hypothesis. NOTE: please cover topics of Crispr/Cas9, HDR, PAM site, Donor sequence, Detection of Modified Allele, Off-targets, etc. Specifics about microRNA-196 are not essential. Limit your answer to 3 pages (single-spaced).
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Week 4 BUS 308 discussions (updated)
/in /by adminDiscussion 1-
Earlier we discussed issues with looking at only a single measure to assess job-related results. Looking back at the data examples you have provided in the previous discussion questions on this issue, how might adding confidence intervals help managers understand results better?
Discussion 2-
Chi-square tests are great to show if distributions differ or if two variables interact in producing outcomes. What are some examples of variables that you might want to check using the chi-square tests? What would these results tell you?
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art HW
/in /by adminDiscussion Questions:
Why would ephermal/temporary work be of value in today’s culture?
In what ways does Goldsworthy preserve/elevate the integrity of his work?
Video link
https://bblearn.nau.edu/bbcswebdav/pid-2998709-dt-content-rid-25038870_1/xid-25038870_1
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CJUS285-1403A-02 Juvenile Delinquency Individual Project 1
/in /by adminCJUS285-1403A-02 Juvenile Delinquency | |
Task Name: | Phase 1 Individual Project |
Deliverable Length: | 600–900 words |
Details: |
Weekly tasks or assignments (Individual or Group Projects) will be due by Monday and late submissions will be assigned a late penalty in accordance with the late penalty policy found in the syllabus. NOTE: All submission posting times are based on midnight Central Time. If you were a state legislator, and you had the opportunity to rework the juvenile justice system, would it be to the advantage of the taxpayer and the juveniles to split the juvenile courts into two sections? For example, one section would handle status offenders, and one section would handle juvenile delinquents.
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